According to the Centers for Disease Control and Prevention (CDC), six in ten Americans live with at least one chronic disease. The World Health Organization (WHO) states that chronic, or non-communicable, disease accounts for almost 70% of deaths world wide. Chronic disease is the leading cause of death and disability in America, and the leading driver of health care costs. According to the Department of Health and Social Services (DHSS), cardiovascular disease is the leading cause of death in Delaware, followed by cancer, lung disease, and diabetes.

The following list of diseases are considered chronic by the CDC, the WHO and other health organizations: