The central dogma that has ruled neuroscience since the early ’90s tells us toxic plaques of amyloid and tangles of tau kill neurons and cause Alzheimer’s. But what about the 30% of older adults who have brains loaded with enough amyloid or tau to meet the criteria for an Alzheimer’s diagnosis, but no outward symptoms of dementia? New research published yesterday in Science Translational Medicine points toward a key driver of such resilience: a family of proteins that act as a master regulator in the brain, preventing neurons from firing out of control.
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Alzheimer’s Brains but no Dementia